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The Biological Weapons Paradox

  • Writer: Jonathan Luckett
    Jonathan Luckett
  • Sep 22, 2025
  • 1 min read

🦠 This Week on the AI Ascent podcast with Dr. Jonathan Luckett: The Pandemic Engineering Challenge 🦠


Here's a chilling but crucial insight from the RAND report that Dr. Jonathan Luckett breaks down this week: while AI could theoretically supercharge biological weapons development, creating a truly extinction-level pandemic faces a fundamental paradox. The very characteristics that make a pathogen deadly enough to threaten human extinction—extreme lethality, rapid onset, resistance to treatment—actually work against its ability to spread globally before burning itself out.


The researchers discovered that engineering a pathogen capable of killing every human on Earth would require solving contradictory biological puzzles. You need something that spreads like wildfire but kills slowly enough to reach every corner of the globe, that's lethal enough to overcome medical countermeasures but stable enough to survive transmission across diverse environments and populations. Even with AI assistance in genetic engineering and deployment strategies, the biological constraints are immense. Natural evolution has been "trying" to create such pathogens for millions of years without success.


What makes this analysis particularly sobering is how it illuminates the difference between catastrophic and extinction-level threats. AI could certainly help create biological weapons that cause massive casualties and societal collapse—that's the real near-term concern. But the complete elimination of humanity through engineered pathogens faces barriers that even advanced AI might not overcome. Dr. Luckett explores what this means for biosecurity policy and why focusing on catastrophic rather than extinction scenarios might be more productive. 🎧.


Listen to the full episode here: https://bit.ly/4pxVhFN


 
 
 

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